Detoxification of mycotoxins

TABLE I
Detoxification by Pathway

MycotoxinDetox PathwayDietary SupplementFood
  Ochratoxin Sterigmatocystin T-2 toxin (trichothecene) Zearalenone Alternaniol DON  (deoxynivalenol)                                                       Glucoronidation  Quercetin, Curcurmin Reserveratrol CBD Ellagic acid  Astaxanthincruciferous vegs., turmeric root, curry powder citrus fruits grapes, berries, pomegranate, walnuts,black currants, algae, salmon, trout, krill, shrimp, crayfish
  Trichothecene                                           Acetylation  Quercetin Garlic  processed meats, grilled meats
  DON T-2 Toxin Sulfation            Retinoic acid caffeine                   fish, arugula, artichoke, green & black tea
  Ochratoxin A DON  Glutathione conjugation  GSH Assist Genisteinberries, grapes, pomegranate, walnuts, fermented soy, black currants
  Aflatoxin B-1CYP 1A2  Resveratrol (+) Quercetin (-) Curcuminm (-)cruciferous veg, green tea,chicory root  
  Aflatoxin B-1CYP 3A4  Curcuminm Resveratrol(­-)    turmeric root curry powder
  Aflatoxin B-1 Aflatoxin G-1 Sterigmatocystin           CYP 1B1  Resveratrol (-) Curcumin Indol-3-carbinolcruciferous veg, turmeric root curry powder  
Ochtatoxin AAmino acid conjugationGlycine Taurine Glutamine Ornithine ArginineTurkey, pork, chicken, pumpkin seeds
Ochtatoxin AMicrobial hydrolysis(gut)   
AlternariolMethylation conjugation    

TABLE II
Detoxification by Organ System

MycotoxinOrgan System for DetoxSupplemental Support
  Ochratoxin A Zearalenone Citrinin AFB-1 Patulin                   Renal (Urinary)Renelix, increased fluid intake
  Ochratoxin A Zearalenone T-2 Toxin (trichothecene) AFB-1 DON    Gastroinestinal (Fecal)ToxEase GL or caps Chicory inulin
  Ochatoxin A  Zearalenone                   Enterohepatic Circulation             Bitters, Ox bile, globe artichoke, Phosphatidyl choline  

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